A One-pot Synthesis, Characterization and Pharmacological Investigations: Schiff Bases
نویسندگان
چکیده
Two biologically active Schiff bases, C13H10BrON (4), C13H9Br2O2N (5), were synthesized by the reaction of 2-aminophenol (1) with 3-bromobenzaldehyde (2) or 3,5-dibromo-4hydroxybenzaldehyde (3) in the presence of conc. H2SO4. The characterization of Schiff bases were carried out by using spectroscopic techniques including IR, H-NMR, FAB-MS along with elemental analyses. The Schiff bases were checked for biological screening and Schiff base (4) was found to be potent antioxidant agent while Schiff base (5) showed non-significant antioxidant activity. In enzyme inhibition, the lipoxygenase inhibition activity was found to be moderate for Schiff base (4) and significant for Schiff base (5). The Schiff bases (4-5) also have excellent antibacterial activity for strains; Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Salmonella typhi and Pseudomonas aeruginosa, using gentamicin as standard drug. Keyword: Schiff base, lipoxygenase inhibition activity, urease inhibition activity
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